Is It Safe To Take Benadryl And Zyrtec At The Same Time. When use nasal spray either standing upright 11 apr claritin class medications. The only difference would be that zyrtec won't cross the. You need to make an appointment with you and her doctor. She is living on the edge.Even if there is no contradiction she is over loaded and probably toxic. Best Answer: My doctor gave me a list of medicines safe to take in pregnancy. For sinus/ colds you can take. Claritin Zyrtec I wouldn't know the answer for that, so anyone can remake the answer if they wish to. I believe it would not be safe though, considering its two. Like cetirizine (zyrtec) or loratadine (claritin), instead of benadryl antihistamines like chlor trimeton and are safe for pregnant women to take (as the less sedating claritin zyrtec). Taking. Although it is not recommended to take Claritin and Benadryl together, it is possible to take Benadryl with other drugs. Like always, you should discuss your treatment with a doctor before you mix your current prescription medicines with Benadryl. Can patients take Benadryl and Claritin together If there are no heart, blood pressure, urinary or kidney contraindications this combination will not likely be a problem. These antihistamines are generally safe medicines. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Feola on can i take benadryl and claritin together: Taking Loratadine in the morning and Diphenhydramine at night will help you avoid the drowsiness side effects of Diphenhydramine and help you if the Loratadine is not controlling your symptoms for the full 24 hours.